Thyroid Disease in Pregnancy: New Insights in Diagnosis and Clinical Management
Some latest research has also shown the reference ranges to be not necessarily the best cut-off for identifying pregnancies at high risk of adverse outcomes. Also, thyroid peroxidase autoantibody positivity and high or low concentrations of HCG seem to have a more prominent role in the interpretation of thyroid dysfunction than previously thought. The review found not much data is available on the effects of thyroid disease treatment, but several studies show clinicians should be aware of the potential for overtreatment with levothyroxine.
The review has included research from last decade on reference ranges for TSH, determinants of thyroid dysfunction, risks of adverse outcomes and options for treatment into perspective. There is also an overview of the current views on thyroid physiology during pregnancy and strategies to identify high-risk individuals who might benefit from levothyroxine treatment.